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目的探讨经肝动脉化疗栓塞术(TACE)联合经皮微波消融治疗(PMCT)巨块型肝癌的临床疗效及应用价值。方法回顾性分析我院经病理、影像学证实的巨块型肝癌70例(病灶>10cm),其中对照组(TACE组)38例仅给予TACE治疗,联合治疗组32例先行TACE治疗2周后再行微波消融治疗。结果 TACE组患者1、2、3年生存率分别为66%、53%和18%,中位生存期18.1个月,联合治疗组患者1、2、3年生存率分别为88%、56%和55%,中位生存期24.0个月,两组生存率比较差异有统计学意义(P<0.05)。结论经肝动脉化疗栓塞术联合微波消融治疗巨块型肝癌疗效好,可成为巨块型肝癌的标准治疗模式之一。
Objective To investigate the clinical efficacy and clinical value of transcatheter arterial chemoembolization (TACE) combined with percutaneous microwave ablation (PMCT) in the treatment of massive liver cancer. Methods Retrospective analysis of pathological, imaging confirmed in our hospital, 70 cases of giant hepatocellular carcinoma (lesions> 10cm), 38 cases in the control group (TACE group) were given only TACE treatment group, 32 cases of TACE treatment for 2 weeks Then microwave ablation. Results The 1-, 2- and 3-year survival rates of TACE group were 66%, 53% and 18%, respectively. The median survival time was 18.1 months. The 1, 2 and 3-year survival rates of the combination group were 88% and 56% And 55%, respectively. The median survival time was 24.0 months. There was significant difference in survival rate between the two groups (P <0.05). Conclusion Transcatheter arterial chemoembolization combined with microwave ablation for the treatment of giant hepatocellular carcinoma has good curative effect and may become one of the standard treatment modalities for massive liver cancer.