论文部分内容阅读
目的:探讨妊娠期糖尿病(GDM)患者体内巨噬细胞移动抑制因子(MIF)水平变化及其与血糖(Glu)水平的关系。方法:ELISA法检测GDM、2型糖尿病(T2DM)患者血清MIF;采用高效液相法检测GHbA1C,采用生化法检测Glu。结果:GDM组及T2DM组MIF水平高于正常对照组,但MIF水平在GDM患者及T2DM组无统计学差别。T2DM组MIF与Glu水平均呈正相关(r=0.826,P<0.001),GHbA1C与Glu呈正相关(r=0.471,P<0.05)。GDM组MIF与Glu水平均呈正相关(r=0.605,P<0.01),GHbA1C与Glu水平呈正相关(r=0.528,P<0.01),正常对照组内各指标间无相关性。GDM组血清MIF水平与孕龄呈正相关(r=0.938,P<0.001)。结论:GDM及糖尿病患者血糖及GHbA1C水平可致患者MIF高表达。高水平MIF可能对妊娠过程产生影响,应引起临床重视。
Objective: To investigate the changes of macrophage migration inhibitory factor (MIF) in patients with gestational diabetes mellitus (GDM) and its relationship with the level of blood glucose (Glu). Methods: Serum MIF was detected by ELISA in patients with GDM and type 2 diabetes mellitus (T2DM). GHbA1C was detected by high performance liquid chromatography and Glu was detected by biochemical method. Results: MIF levels in GDM group and T2DM group were higher than those in normal control group, but there was no significant difference in MIF level between GDM group and T2DM group. There was a positive correlation between MIF and Glu levels in T2DM patients (r = 0.826, P <0.001) and GHbA1C was positively correlated with Glu (r = 0.471, P <0.05). There was a positive correlation between MIF and Glu levels in GDM group (r = 0.605, P <0.01). There was a positive correlation between GHbA1C and Glu levels (r = 0.528, P <0.01). There was no correlation between MIF and Glu levels in GDM group. Serum MIF levels in GDM group were positively correlated with gestational age (r = 0.938, P <0.001). Conclusion: The blood glucose and GHbA1C level in patients with GDM and diabetes mellitus can cause MIF overexpression. High levels of MIF may have an impact on the pregnancy, should cause clinical attention.