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目的:研制一种能防治铅中毒的食用保健盐。方法:用含0-25 % 醋酸铅的饮料喂养SD 大鼠复制铅中毒模型,同时用不同浓度碘化钾(KI) 盐水( 分别为10 mg·kg·d - 1 ,20 mg·kg·d- 1 和30 mg·kg·d - 1) 分组喂养,探索预防铅中毒的KI日需量。然后制成含KI1 % 的食盐,供50 名铅作业工人烹饪菜肴后食用;在服用KI盐前后测定血ZPP,Hb 、血铅、尿δALA,并动态观察尿铅排泄情况。结果:动物日需KI10 mg·kg·d - 1则具有抗铅性损害作用;铅接触人员服KI盐后第3 d 尿排铅量增加,第9 d 达高峰,第4 周达正常,服用KI盐前后Hb ,ZPP,δALA,血Pb ,NAG,Rp 依次为(101-2 和128)g·L- 1( P = 0 .05) ,(33-5 和7-7)μg·g - 1 Hb( P< 0 .01) ,(123-12 和65-36)μmol·L-1( P < 0 .05) ,(2-123 和0-85)μmol·L-1( P < 0 .01) ,(20-9 和6-7)U·L- 1(P < 0 .01) ,(1-5 和0-34)mg·L- 1( P < 0 .05) 。结论:铅接触人员摄入1 % KI的食盐有驱铅及预防铅性损害作用
Objective: To develop a kind of edible health salt that can prevent lead poisoning. Methods: The model of lead poisoning in SD rat was fed with 0-25% lead acetate beverage. The rats were treated with KI saline (10 mg · kg · d-1, 20 mg · kg · d-1, 30 mg · kg · d - 1) group feeding, to explore the prevention of lead poisoning KI daily demand. And then made into salt containing KI1%, for 50 lead workers cooking food after eating; before taking the KI salt determination of blood ZPP, Hb, blood lead, urine δ ALA, and dynamic observation of urinary lead excretion. Results: KI 10 mg · kg · d - 1 on the day of the animals had the anti - lead effect. The lead excretion of urine increased on the 3rd day after exposure to KI salt, reached the peak on the 9th day, reached the normal on the 4th week, The values of Hb, ZPP, δALA, blood Pb, NAG and Rp before and after KI were (101-2 and 128) g · L -1 (P = 0.05), (33-5 and 7-7) μg · (P <0.01), (123-12 and 65-36) μmol·L -1 (P <0.05), (2-123 and 0-85) μmol·L -1 P <0.01), (20-9 and 6-7) U · L -1 (P <0.01), (1-5 and 0-34) mg · L -1 (P <0.05). Conclusion: Exposure of lead to 1% KI to lead exposure may lead and prevent lead damage