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目的探讨结核性脑膜炎患儿血清中神经元特异性烯醇酶(NSE)含量的变化及临床意义.方法采用酶联免疫法测定49例结核性脑膜炎患儿和15例对照组血清中NSE含量.结果49例结核性脑膜炎患儿血清中NSE含量比15例对照组明显升高,差异有非常显著性意义(t=3.56,P<0.01)结核性脑膜炎患儿血清中NSE含量,随着临床分期加重而升高,差异有非常显著性意义(P<0.01).有后遗症组血清NSE含量比无后遗症组明显升高,差异有非常显著性意义(t=3.71,P<0.01).结论血清中NSE含量的变化对结核性脑膜炎患儿脑损伤程度及临床预后判断有重要参考价值.
Objective To investigate the changes of serum neuron specific enolase (NSE) in children with tuberculous meningitis and its clinical significance.Methods Serum levels of NSE in 49 children with tuberculous meningitis and 15 controls were detected by enzyme-linked immunosorbent assay Content.Results Serum levels of NSE in 49 cases of children with tuberculous meningitis were significantly higher than those in 15 cases (P0.05), the difference was statistically significant (t = 3.56, P0.01) (P0.01) .The serum NSE level in sequelae group was significantly higher than that in sequelae group, the difference was significant (t = 3.71, P <0.01) .Conclusion The change of serum NSE content has important reference value for the degree of brain injury and clinical prognosis in children with tuberculous meningitis.