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目的:探讨奥扎格雷钠联合川芎嗪注射液对急性脑梗死患者血清同型半胱氨酸(HCY)、C反应蛋白(CRP)及纤维蛋白原(FIB)的水平的影响。方法:选择我院收治的急性脑梗死患者68例,随机分为实验组与对照组,每组34例。对照组患者给予奥扎格雷钠治疗,实验组患者给予奥扎格雷钠联合使用川芎嗪注射液治疗,观察并比较治疗前后两组患者血清HCY,CRP及FIB的水平以及颈内动脉粥样狭窄程度的变化和临床总有效率。结果:与治疗前相比,两组患者血清HCY,CRP及FIB水平均显著降低,颈内动脉粥样硬化情况均好转(P<0.05);且与对照组相比,实验组患者血清HCY,CRP及FIB水平较低,颈内动脉粥样硬化情况较轻(P<0.05);与对照组相比,实验组患者临床总有效率较高(P<0.05)。结论:奥扎格雷钠联合川芎嗪注射液治疗可显著提高急性脑梗死积的临床疗效,并能够降低患者颈内动脉粥样狭窄程度,其机制可能与降低血清HCY,CRP及纤维蛋白原水平有关。
Objective: To investigate the effects of sodium ozagrel combined with ligustrazine on serum levels of homocysteine (HCY), C-reactive protein (CRP) and fibrinogen (FIB) in patients with acute cerebral infarction. Methods: A total of 68 acute cerebral infarction patients admitted to our hospital were randomly divided into experimental group and control group, with 34 cases in each group. Patients in the control group were treated with ozagrel sodium. Patients in the experimental group were treated with ozagrel sodium in combination with ligustrazine injection. The levels of serum HCY, CRP and FIB and the degree of internal carotid artery atherosclerosis in both groups before and after treatment were observed and compared The change and total clinical efficiency. Results: Compared with those before treatment, serum HCY, CRP and FIB levels were significantly lower and carotid artery atherosclerosis were improved in both groups (P <0.05). Compared with the control group, serum HCY, The levels of CRP and FIB were lower, and the carotid atherosclerosis in the carotid artery was less severe (P <0.05). Compared with the control group, the total effective rate of the experimental group was higher (P <0.05). Conclusion: Ozagrel sodium combined with Ligustrazine injection can significantly improve the clinical efficacy of acute cerebral infarction and reduce the degree of carotid artery atherosclerosis, which may be related to the reduction of serum HCY, CRP and fibrinogen levels .