论文部分内容阅读
很多作者假设食用鱼油所引起的代谢变化与前列腺素的代谢变化有关。由于二十碳五烯酸的结构与前列腺素的前体花生四烯酸相似,现被认为是鱼油中的活性脂肪酸。花生四烯酸由ω-6族脂肪酸衍生形成,并可生成前列腺素双烯系和白三烯的“4”系。而二十碳五烯酸则为ω-3族脂肪酸衍生物,可以合成前列腺素的三烯系和白三烯的“5”系。这两类前列腺素和白三烯的生物活性并不相同。由血小板利用花生四烯酸生成的血栓素A_2,是很强的血小板聚集因子和血管收缩素,而由二十碳五烯酸产生的血栓素A_3,能收缩血管却不能聚集血小板。花生四烯酸生成的白三烯B_4,具有很强的中
Many authors hypothesize that the metabolic changes caused by consumption of fish oil are related to the metabolic changes of prostaglandins. Eicosapentaenoic acid is now considered to be an active fatty acid in fish oil because of its structure similar to that of prostaglandin, arachidonic acid. Arachidonic acid is derived from omega-6 fatty acids and forms the “4” system of prostaglandin diacetyles and leukotrienes. Eicosapentaenoic acid, however, is an omega-3 fatty acid derivative that synthesizes the “5” system of the triene and leukotrienes of prostaglandins. The biological activity of these two types of prostaglandins and leukotrienes are not the same. Thromboxane A 2, which is produced by platelets using arachidonic acid, is a very strong platelet aggregation factor and angiotensin. Thromboxane A 3, produced by eicosapentaenoic acid, can vasoconstrict and can not aggregate platelets. Arachidonic acid generated leukotriene B_4, with a strong