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目的 :对 12 7例不同年龄结构的正常人群和 2 8例膀胱肿瘤患者尿中 EGF水平进行测定。 方法 :采用I1 2 5 - EGF的放射免疫法测定 EGF水平。 结果 :小儿组 (15例 ) EGF浓度 (31.19± 7.46 ) μg/L;正常人群组 (92例 )EGF浓度 (16 .5 2± 1.6 9)μg/L ;膀胱肿瘤组 (2 8例 ) EGF浓度 (14.6 4± 1.86 )μg/L ;前列腺增生组 (BPH,2 0例 ) EGF浓度 (7.91± 1.11)μg/L。膀胱肿瘤组与正常人群组比较有统计学差异 (P <0 .0 5 ) ;年龄的变化也有统计学差异 (P<0 .0 5 )。 结论 :EGF与年龄有相关性 ;EGF是一个较可靠、灵敏的指标有助于膀胱肿瘤的早期诊断
OBJECTIVE: To determine urinary levels of EGF in 127 normal subjects of different ages and 28 patients with bladder cancer. Methods: EGF levels were determined by radioimmunoassay with I1 2 5 - EGF. Results: The EGF concentration in pediatric group (31.19 ± 7.46) μg / L and the normal group (92 cases) were significantly higher than those in normal bladder group (16.52 ± 1.6 9 μg / L) EGF concentration (14.64 ± 1.86) μg / L; BPH group (BPH, 20 cases) EGF concentration (7.91 ± 1.11) μg / L. There was a significant difference between bladder cancer group and normal group (P <0.05), and there was also a significant difference in age (P <0.05). Conclusion: There is a correlation between EGF and age. EGF is a reliable and sensitive indicator for the early diagnosis of bladder cancer