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随着影像诊断技术的广泛应用和改进,胰腺囊性肿瘤(PCN)的诊断率不断增加。常见的胰腺囊性肿瘤包括浆液性囊腺瘤(SCN)、黏液性囊腺瘤(MCN)和导管内乳头状黏液性肿瘤(IPMN)以及囊实性假乳头状肿瘤(SPN),一旦怀疑为恶性时,均应行根治性手术切除。PCN的术前诊断和良恶性判断十分重要,目前主要依靠临床表现、影像学检查和实验室检查。当临床发现老年男性病人、血清肿瘤标记物CA19-9升高、伴有巨大胰腺肿块、体重下降、有特征性影像学表现者,应考虑恶性肿瘤的可能。主要依靠术后病理、经超声内镜下囊液抽取分析和穿刺组织活检确诊,包括肿瘤相关DNA、MicroRNA和蛋白质标记物的分析。
With the extensive application and improvement of imaging diagnostic techniques, the diagnosis rate of pancreatic cystic neoplasm (PCN) is increasing. Common pancreatic cystic tumors include serous cystadenoma (SCN), mucinous cystadenoma (MCN) and intraductal papillary mucinous neoplasm (IPMN) and cystic pseudopapillary tumors (SPN), once suspected Malignant, should be performed radical surgical resection. Preoperative diagnosis of PCN and benign and malignant judgment is very important, mainly rely on clinical manifestations, imaging studies and laboratory tests. When clinical findings in elderly male patients, elevated serum tumor markers CA19-9, accompanied by huge pancreatic mass, weight loss, a characteristic imaging findings, should consider the possibility of malignant tumors. Mainly rely on postoperative pathology, ultrasound endoscopic cyst fluid extraction and biopsy biopsy diagnosis, including tumor-associated DNA, MicroRNA and protein markers analysis.