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目的考察橄榄油对氟比洛芬和双氯芬酸钠透过大鼠腹部皮肤的作用。方法以离体大鼠腹部皮肤为渗透屏障,采用扩散池装置,以预处理皮肤法考察橄榄油对药物透过皮肤的影响。结果 榄油可有效促进氟比洛芬的经皮透过率,增渗倍数为2.11,但对双氯芬酸钠的经皮透过率有抑制作用。结论橄榄油能够促进氟比洛芬的经皮渗透,可能归因于其中油酸的存在,还可能含有某些成分对双氯芬酸钠的经皮渗透有抑制作用。
Objective To investigate the effect of olive oil on flurbiprofen and diclofenac sodium through the abdominal skin of rats. Methods The abdominal skin of isolated rat was taken as the osmotic barrier. The diffusion device was used to examine the effect of olive oil on the skin through the skin pretreatment method. The results of olive oil can effectively promote the permeability of flurbiprofen transdermal permeabilization multiples of 2.11, but diclofenac sodium percutaneous permeability inhibition. Conclusion Olive oil can promote the transdermal permeation of flurbiprofen, which may be attributed to the presence of oleic acid, and may also contain certain components of diclofenac sodium transdermal penetration inhibition.