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目的：观察不同程度高血压患者血清β2-微球蛋白（β2-MG）与糖化白蛋白（GA-L）水平变化，探讨两者在不同程度高血压中的临床应用价值。方法不同程度高血压患者80例，按血压水平分为3组，高血压1级组15例，高血压2级组30例，高血压3级组35例。同期健康体检者80例（健康对照组）。平行检测两组人群TG、TC、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、超敏C反应蛋白（hs-CRP）、肌酐（Scr）、尿素氮（BUN）、GA-L、β2-MG水平，询问有无吸烟、酗酒及各种其他病史。结果不同程度高血压患者3组比较，吸烟、酗酒、各种其他病史、TG、TC、LDL-C、HDL-C、Scr、BUN水平差异均无统计学意义（P＞0.05）；两组人群间hs-CRP、β2-MG和GA-L水平差异均有统计学意义，且高血压3级组较1级组、2级组和健康对照组明显升高；hs-CRP与β2-MG、GA-L呈正相关（r=0.325,P=0.004；r=0.287,P=0.012）,β2-MG与GA-L亦呈正相关（r=0.594,P=0.000）；血清hs-CRP、β2-MG、GA-L水平与不同程度高血压患者肾脏损害严重程度均呈高度正相关（r分别为0.571，0.679，0.547，均P＜0.01）。结论不同程度高血压患者血清hs-CRP、β2-MG和GA-L水平互为相关，β2-MG和GA-L用于评估高血压患者肾脏损害的程度及治疗效果具有一定的临床应用价值。“,”Objective To investigate the changes between serum β2-MG and GA-L in patients with different degrees hypertension and discuss the value of clinical application in different degrees hypertension.Methods Lipids,hs-CRP,β2-MG,Scr,BUN,GA-L,history of smoking,drinking,diabetes mellitus and other diseases were analyzed in 80 patients with essential hypertension,which were classified based on blood pressure level:15 in group 1,30 in group 2,35 in group 3.80 health examination volunteer served as control. Results There were no significant differences in age,TC,TG,LDL-C,HDL-C,Scr,BUN,duration of hypertension and ratio of diabetes,coronary heart disease,gender,drinking,smoking among patients in three groups(P>0.05).Compared with hypertensive group 1 group 2 and control group,β2-MG hs-CRP,GA-L were significant higher in patients in group 3;Hs-CRP was positively correlated with β2-MG and GA-L(r=0.325,P=0.004;r=0.287,P=0.012),β2-MG was also positively correlated with GA-L(r=0.594, P=0.000);The levels between serum hs-CRP、β2-MG、GA-L was positively correlated with target-organ damage of hypertension degrees(r=0.571, 0.679,0.547,P<0.01).Conclusionsβ2-MG,hs-CRP GA-L are positively correlated each other,detection of β2-MG and GA-L is an important access to target organ damage in patients with essential hypertension.