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研究显示感染或炎症(特别是妊娠早期)可以促成早产;妊娠中3月羊水中炎症性细胞因子水平与分娩时孕龄呈负相关。鉴于炎性细胞因子具有多源性(既可源于母亲血循环、子宫内局部防御系统,也可源于胎儿血循环和胎膜),因此,要确定其确切源处较难。推测倘若母亲有与早产风险增加有关的早期炎症反应,有可能会在妊娠中3月(15～19周)表现为母亲血中免疫球蛋白生成增加。为此进行一项巢式病例对照研究,分析比较了足月分娩和早产妇女妊娠中3月血清免疫球蛋白水平。
Studies have shown that infection or inflammation, particularly in early pregnancy, can contribute to preterm birth; the level of inflammatory cytokines in amniotic fluid in March is negatively correlated with gestational age at delivery. In view of the multi-source of inflammatory cytokines (both from the mother’s blood circulation, intrauterine local defense system, but also from fetal blood circulation and fetal membranes), to determine its exact source more difficult. It is speculated that if mothers have an early inflammatory response associated with an increased risk of preterm birth, there may be an increase in immunoglobulin production in the maternal blood during the third trimester of pregnancy (15-19 weeks). To do this, a nested case-control study was conducted to analyze the levels of serum immunoglobulins in term pregnancies and maternal pregnancies in March.