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目的:观察高频电波刀宫颈电圈环切术(LEEP)系列手术联合应用七味消糜散治疗宫颈上皮内瘤变(CI N)伴人乳头瘤病毒(HPV)感染的临床效果。方法:对202例慢性宫颈炎、CINⅠ～Ⅲ伴HPV阳性患者进行LEEP手术治疗,分别于术后12个月、18个月检测其宫颈HPV-DNA的负荷量,同时行阴道镜检查及宫颈活检。结果:术后12个月,约70%CINⅠ～Ⅲ病例转为慢性炎症;宫颈HPV表达明显下降,转阴率82.18%,低HPV负荷组与高HPV负荷组两组之间CIN转归存在显著差异(P=0.000)。结论:LEEP联合七味消糜散治疗可以有效控制CIN的进一步发展,同时可明显降低宫颈HPV表达。联合治疗后宫颈病变的转归与术后高危型HPV的负荷量的高低密切相关。
Objective: To observe the clinical effect of high frequency electrosurgical excision and cervical loop electrosurgical excision (LEEP) series operation combined with Qiwei Xiaomi Powder in treating cervical intraepithelial neoplasia (CI N) with human papillomavirus (HPV) infection. Methods: 202 cases of chronic cervicitis, CIN Ⅰ ~ Ⅲ with HPV-positive patients were treated with LEEP, respectively, at 12 months and 18 months after the detection of HPV-DNA load, while colposcopy and cervical biopsy . Results: In the 12 months after operation, about 70% of CINⅠ-Ⅲ cases turned to chronic inflammation. The HPV expression of cervix was significantly decreased, with a negative conversion rate of 82.18%. There was significant difference in CIN between the two groups Differences (P = 0.000). Conclusion: LEEP combined with Qi Wei Xiao Mi San treatment can effectively control the further development of CIN, and can significantly reduce cervical HPV expression. The outcome of cervical lesions after combined treatment is closely related to the level of high-risk HPV load.