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目的：探讨妊娠高血压综合征（PIH）患者外周静脉血清、新生儿脐静脉血清及胎盘组织中丙二醛（MDA）和超氧化物歧化酶（SOD）含量的变化及与PIH发生、发展的关系。方法：以PIH27例为研究组，测定其外周静脉血清，新生儿脐静脉血清及胎盘组织中的MDA和SOD，并比较了分娩前、后的变化，以年龄相近的20例正常孕妇作为对照组。结果：PIH患者的MDA含量按轻、中、重程度不同较正常晚期妊娠者逐渐增高（P＜0．01），二者呈正相关（r＝0．939，r＝0．925，r＝0．961，均P＜0．01）；PIH患者的SOD含量按轻、中、重程度不同较正常孕妇者逐渐降低（P＜0．01），二者呈负相关（r＝－0．925，r＝－0．937，r＝－0．954，均P＜0．01）；PIH患者分娩后MDA含量下降（P＜0．01），而SOD含量升高（P＜0．01）。结论：PIH的发生、发展与体内氧化与抗氧化平衡失调有关。
OBJECTIVE: To investigate the changes of malondialdehyde (MDA) and superoxide dismutase (SOD) in peripheral vein serum and neonatal umbilical vein blood and placental tissue in patients with pregnancy induced hypertension (PIH) and their relationship with the occurrence and development of PIH relationship. Methods: Twenty-seven PIHs were used as the study group to determine the changes of MDA and SOD in peripheral vein serum, neonatal umbilical vein serum and placenta tissue and compare the change before and after delivery, with 20 normal pregnant women with similar age as the control group . Results: The levels of MDA in PIH patients were significantly higher than those in patients with normal late pregnancy (P <0.01) according to their light, moderate and severe degree (r = 0.939, r = 0.925, r = 0 .961, all P <0.01). The levels of SOD in PIH patients were lower than those in normal pregnant women according to their lightness, moderate and severe degree (P <0.01) , R = -0.937, r = -0.954, all P <0.01). The PIH patients had lower MDA content and higher SOD content after delivery (P <0.01) . Conclusion: The occurrence and development of PIH are related to the imbalance of oxidation and antioxidation in vivo.