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目的探讨我国儿童及母亲孕期接触农药与儿童白血病的关系。方法对检索国内外数据库得到的12篇关于我国儿童及母亲孕期接触农药与儿童白血病关系的文献进行Meta分析。结果儿童及母亲孕期接触农药可增加儿童患白血病的风险(OR=2.28,95%CI:2.01~2.59)。按照地区、对照来源、样本量、调查时间、接触方式进行分组,亚组分析结果显示,各亚组儿童及母亲孕期接触农药均可增加儿童患白血病的风险。结论儿童及母亲孕期接触农药是儿童白血病的危险因素。
Objective To explore the relationship between Chinese children and their mothers during pregnancy exposure to pesticides and childhood leukemia. Methods A meta-analysis of 12 articles retrieved from databases at home and abroad about the relationship between Chinese children and their mothers during their pregnancy with childhood leukemia was conducted. Results Exposure of children and their mothers to pesticides during pregnancy increased the risk of childhood leukemia (OR = 2.28, 95% CI: 2.01-2.59). According to the region, source of control, sample size, investigation time and contact mode, the subgroup analysis showed that children and their mothers in each subgroup could increase the risk of leukemia when they were exposed to pesticides during pregnancy. Conclusion Children and mothers during pregnancy exposure to pesticides are risk factors for childhood leukemia.