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以平阳霉素为诱变剂，观察１５例下咽癌患者和２３例正常人外周血淋巴细胞染色体对诱变剂的敏感性。结果显示，下咽癌患者的染色体畸变率、细胞染色单体断裂率和畸变细胞率分别为１．９９±０．０８％，６５．１０％±１．７５％和４０％±１．７９％，明显高于正常对照组（０．９４％±０．０４％，２８．０９％±１．３３％和２６．５２％±１．３０％）。细胞染色单体断裂率大于４０％和６０％者，下咽癌组分别为８６．６７％和６０％，对照组分别为１３．０４％和０。细胞染色单体断裂率大于４０％，应视为患下咽癌风险者。
To Pingyangmycin as a mutagen, observed in 15 cases of hypopharyngeal cancer patients and 23 cases of normal peripheral blood lymphocyte chromosome sensitivity to mutagens. The results showed that the chromosome aberration rate, chromatid breakage rate and aberrant cell rate in hypopharyngeal carcinoma patients were 1.99 ± 0.08%, 65.10% ± 1.75% and 40% ± 1.79%, respectively (0.94% ± 0.04%, 28.09% ± 1.33% and 26.52% ± 1.30%, respectively). Cell chromatid cleavage rate was greater than 40% and 60%, hypopharyngeal cancer group were 86.67% and 60%, respectively, the control group were 13.04% and 0. Cell chromatid cleavage rate greater than 40%, should be considered as at risk of pharyngeal cancer.