论文部分内容阅读
目的分析计划免疫人群在麻疹疫情发生时体内抗体水平,探讨麻疹疫苗在麻疹高发季补种的必要性。方法采集涉及疫情的152例患者/密接者的血清标本,运用酶联免疫法(ELISA)检测样本的血清中麻疹特异性IgM、IgG抗体,根据抗体分布水平情况,分析计划免疫人群在麻疹疫情发生时体内抗体水平变化的规律。结果 (1)在152例样本中,25例为IgM抗体阳性,阳性率16.45%,且IgM阳性率随监测时间推移而出现明显下降。血清IgG抗体检测147例阳性,阳性率为97.25%。(2)按照IgG水平进行分层分析,结果 IgM阳性例数随IgG水平的增高而增多,人群分布集中在IgG低水平组和高水平组,提示在没有受到病原体刺激时人体内麻疹IgG处于低水平,受到刺激时表现为IgM和/或IgG水平增高,表现出个体差异。(3)根据IgM结果将人群分为IgM阳性组和IgM阴性组,采用秩和检验比较两组的IgG抗体水平,两组IgG水平差异有统计学意义(P=0.012,P<0.05)。结论麻疹高发季节,及时对医护人员进行免疫强化接种,使其免疫功能得到强化十分必要的。
OBJECTIVE: To analyze the level of antibody in the population of planned immunization in the outbreak of measles and to explore the necessity of the vaccination of measles in the high season of measles. Methods Serum samples from 152 patients / intimae involved in the outbreak were collected. Measles-specific IgM and IgG antibodies were detected by enzyme-linked immunosorbent assay (ELISA). According to the antibody distribution level, When the level of antibody in vivo changes. Results (1) In 152 samples, 25 cases were positive for IgM antibody, the positive rate was 16.45%, and the positive rate of IgM decreased obviously with the monitoring time. 147 cases of serum IgG antibody test positive, the positive rate was 97.25%. (2) According to the level of IgG, stratified analysis showed that the number of IgM positive cases increased with the increase of IgG level, and the distribution of the population concentrated in low and high IgG group, suggesting that human measles IgG was low in the absence of pathogen stimulation Levels, when stimulated by an increase in IgM and / or IgG levels, exhibit individual differences. (3) According to IgM results, the population was divided into IgM positive group and IgM negative group. IgG antibody levels of the two groups were compared by rank sum test. There was significant difference between the two groups (P = 0.012, P <0.05). Conclusion In the high incidence season of measles, it is necessary to strengthen the immune function by timely immunization of health care workers.