【摘 要】
：
Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTr was developed harnessing the amino-type excited-state intramolecular proton transfer (ESIPT) process.Relyin
【机 构】
：
Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China;The Molecul
论文部分内容阅读
Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTr was developed harnessing the amino-type excited-state intramolecular proton transfer (ESIPT) process.Relying on whether the ESIPT proceeds normally or not,ABTT exhibited the yellow fluorescence in acidic media,or cyan fluorescence in basic condition.According to the variation,ABTr behaved as a promising sensor which possessed fast and reversible response to pH change without interference from the biological substances,and exported a steady ratiometric signal (I478/I546).Moreover,due to the ESIPT effect,large Stokes shift and high quantum yield were also exhibited in ABTT.Furthermore,ABTT was applied for monitoring the pH changes in living cells and visualizing the pH fluctuations under oxidative stress successfully.These results elucidated great potential of ABTT in understanding pH-dependent physiological and pathological processes.
其他文献
Numerous researchers have paid attention to achieve metal-free phosphorescence by exploring new structures or new mechanisms.Herein,a facile way is introduced to endow a common fluorescence dye,tetrabromofluorescein (4Br-Flu),some fabulous optical charact
Advanced chemotherapy strategies are in urgent demand for improving anticancer efficacy.Herein,a water-soluble pillar[6]arene (WP6A) was used to load chemotherapeutic agent pemetrexed (PMX) by forming direct host-guest inclusion,which is beneficial for de
In the field of volatile organic compounds (VOCs) pollution control,adsorption is one of the major control methods,and effective adsorbents are desired in this technology.In this work,the density functional theory (DFT) calculations are employed to invest
As a kind of environmentally benign reagents,α-keto acids have been extensively employed as key starting materials in organic synthesis.Organic electrosynthesis has the advantages of reducing byproduct generation,improving the cost-efficiency of synthetic
As an important component of the atmosphere,ammonia (NH3) plays a very important role in maintaining the balance of environment.However,it is also one of the most toxic gases that can cause damage to the human respiratory system and mucous membranes even
Carbon-based fluorescent nanomaterials have gained much attention in recent years.In this work,green-photoluminescent carbon nanodots (CNDs;also termed carbon dots,CDs) with amine termination were synthesized via the hydrothermal treatment of amine-contai
Discrimination of glycoproteins and cell types is a significant but difficult issue.Herein,we presented a novel fluorescence sensor array for the detection and identification of glycoproteins and cancer cells based on the specific affinity between boronic
The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year,however pharmacological therapies to act effectively against coronavirus disease 2019 (COVID-19) remain elusive.Chloroquine (CQ),an antimalarial drug,was found t
As organic pollutants of emerging concern,organophosphate esters (OPEs) have shown toxicity to organisms after entering the water environment.However,research on OPEs in freshwater in Southwest China is very limited.The levels,distribution and partitionin
A mesoporous cobalt aluminate (CoAl2O4) spinel is synthesized through a combustion method and adopted for the activation of peroxymonosulfate (PMS) to degrade organic pollutants.Multiple characterization procedures are conducted to investigate the morphol