论文部分内容阅读
目的:探讨膀胱移行细胞癌中血管内皮生长因子(VEGF)的表达及其与临床病理指标的关系.方法:应用免疫组织化学方法,对62例原发性膀胱移行细胞癌及8例正常膀胱组织中VEGF进行检测.结果:正常膀胱移行上皮均为阴性反应,膀胱癌组织中VEGF阳性表达率为56.5%.低分化和浸润性癌中VEGF阳性表达率明显高于高分化和表浅性癌组(P<0.05),复发者阳性表达率明显高于未复发者(P<0.05),WEGF阳性表达者3年生存率明显低于阴性表达者(P<0.05).结论:VEGF表达对膀胱癌生物学行为有重要影响,VEGF表达有可能成为预测膀胱癌复发、转移和预后的一种指标.
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in bladder transitional cell carcinoma and its relationship with clinicopathological parameters.Methods: 62 cases of primary bladder transitional cell carcinoma and 8 cases of normal bladder tissue VEGF in the normal bladder tissue were detected.Results: The normal bladder transitional epithelium was negative, the positive rate of VEGF in bladder cancer was 56.5% .The positive rate of VEGF in poorly differentiated and invasive carcinoma was significantly higher than that in well differentiated and superficial carcinoma (P0.05) .The positive expression rate of recurrence was significantly higher than that of non-recurrence (P0.05) .The 3-year survival rate of WEGF positive expression was significantly lower than that of negative expression (P0.05) .Conclusion: The expression of VEGF in bladder cancer Biological behavior has an important impact, VEGF expression may be a prognostic indicator of bladder cancer recurrence, metastasis and prognosis.