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用高分辨分带技术对人类肿瘤细胞作细胞学分析,发现90％以上的造血细胞恶性肿瘤都有细胞遗传学改变。另外,已有许多文献报道人类白血病的发生与癌基因的活化密切相关,原癌基因c-Ha-ras不仅在膀胱、结肠、肾脏、肝、肺、卵巢、胃、胰腺等癌瘤中发现有激活现象,而且在血液系统中各种类型的白血病中也发现这一基因的激活。ras基因的主要激活形式是点突变,而第12位密码子点突变现象又常常是多种点突变
Cytological analysis of human tumor cells using high-resolution banding technology revealed that cytogenetic changes were observed in more than 90% of hematopoietic malignancies. In addition, there have been many reports that the occurrence of human leukemia is closely related to the activation of oncogenes. The proto-oncogene c-Ha-ras is not only found in bladder, colon, kidney, liver, lung, ovary, stomach, pancreas and other cancers. The phenomenon of activation, and activation of this gene is also found in various types of leukemia in the blood system. The main activating form of the ras gene is a point mutation, and the point mutation at the 12th codon is often a variety of point mutations.