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目的：研究甲状腺机能亢进症（简称甲亢）患者的骨代谢生化指标骨钙素（ＢＧＰ）、骨碱性磷酸酶（ＢＡＬＰ）、抗酒石酸酸性磷酸酶（ＴＲＡＰ）的改变及临床意义。方法：用生化法测定３０ 例甲亢患者血清ＢＧＰ、ＢＡＬＰ、ＴＲＡＰ浓度，并与年龄和性别相匹配的健康志愿者相比较。结果：甲亢患者ＢＧＰ８．９５±３．２９ｎｇ／ｍ ｌ；ＢＡＬＰ１４６．０３±６５．３５ｕ／Ｌ；ＴＲＡＰ１２．６６±５．５７ｕ／Ｌ，都显著高于正常对照组（Ｐ＜ ０．００１）。相关分析显示三者与血清游离Ｔ３（ＦＴ３）呈正相关（ｒ＝ ０．３６５，０．４４７，０．３５３，Ｐ＜０．０５）。结论：甲亢患者成骨、破骨细胞活性增高，骨转换率增高，与甲状腺激素分泌过多有关。
Objective: To study the changes and clinical significance of BGP, BAP and TRAP in patients with hyperthyroidism. Methods: Serum levels of BGP, BALP and TRAP in 30 patients with hyperthyroidism were measured by biochemical methods and compared with age and sex matched healthy volunteers. Results: BGP8.95 ± 3.29ng / ml, BALP146.03 ± 65.35u / L and TRAP12.66 ± 5.57u / L in hyperthyroidism patients were significantly higher than those in normal controls (P <0.001). Correlation analysis showed that the three were positively correlated with serum free T3 (r = 0.365,0.447,0.353, P <0.05). Conclusion: Hyperthyroidism patients with osteogenesis, increased activity of osteoclasts, bone turnover rate increased, and the excessive secretion of thyroid hormone.