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目的比较老年与中青年甲亢患者临床特点及131I治疗效果。方法本研究于2009年5月～2012年5月对不同年龄(≥60岁 VS <60岁)甲亢患者的临床特点进行对比分析,并探讨131I治疗的临床效果。结果老年组与中青年组的甲状腺估重、甲状腺24h摄取131I率比较有明显差异,且差异具有统计学意义(X2=25.44、12.64,P<0.05)。经过积极治疗后,老年组的治疗有效率与中青年组比较无明显差异(X2=0.17,P>0.05)。34例老年组患者中发生甲减5例,发生率为14.71%,90例中青年组患者中发生甲减4例,发生率为4.44%;经统计学比较发现老年组患者的甲减发生率明显高于中青年组,且差异具有统计学意义(X2=3.86,P<0.05)。结论 131I治疗老年与中青年甲亢患者的临床疗效无差异,可作为老年甲亢患者的首选治疗方法。
Objective To compare the clinical characteristics of elderly patients with middle-aged patients with hyperthyroidism and the effect of 131I treatment. Methods The clinical features of patients with hyperthyroidism at different ages (≥ 60 years vs <60 years old) from May 2009 to May 2012 were compared and analyzed, and the clinical effect of 131I treatment was discussed. Results There was a significant difference in thyroid gland weight and thyroid uptake rate of 131I between the elderly group and the middle-aged group, and the difference was statistically significant (X2 = 25.44, 12.64, P <0.05). After active treatment, the effective rate of treatment in the elderly group was no significant difference compared with the young group (X2 = 0.17, P> 0.05). Among the 34 elderly patients, hypothyroidism occurred in 5 cases and the incidence rate was 14.71%. In the 90 cases of middle-aged and young patients, hypothyroidism occurred in 4 cases and the incidence rate was 4.44%. The incidence of hypothyroidism in the elderly group was found by statistical comparison The difference was statistically significant (X2 = 3.86, P <0.05). Conclusion 131I treatment of elderly patients with hyperthyroidism no difference between the clinical efficacy can be used as the preferred treatment of elderly patients with hyperthyroidism.