An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pan- creat

• 作 者: Rong-Li Piao Ming Xiu David R
• 机 构: DepartmentofHepatic-biliary-pancreaticMedicine,TheResearchInstituteatNationwideChildren',sHospita
• 出 处: 国际肝胆胰疾病杂志：英文版
• 发表日期: 2015年6期
• 关键词: 胰腺外分泌 细胞模型 细胞免疫 纤维化 炎症 永生化 评价 大鼠 pancreatic stellate cell pancreatic fibrosis
• 基金项目: support by grants from the National Natural Science Foundation of China(81070370 and 81270544)

BACKGROUND: Pancreatic stellate cells(PSCs) play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells,immune cells or intermediaries in pancreatic exocrine secretion. Increasing evidence has shown that