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目的调查2型糖尿病(T2DM)与肾细胞癌(RCC)的关系,了解糖尿病是否为肾细胞癌的危险因素。方法收集肾细胞癌患者280例,依患者是否患有2型糖尿病,分为肾细胞癌组(RCC组),共122例,肾细胞癌+2型糖尿病组(RCC+T2DM),共158例。记录并分析两组患者的年龄、性别、肾细胞癌的大小及分期、糖化血清蛋白(GSP)、血清肌酐(Cr)、空腹血糖(FBG)等指标的差异。结果 (1)肾细胞癌的280例患者中,158例患有糖尿病。有2型糖尿病病史的肾细胞癌患者女性的数量(94例)相比男性(64例)更多。(2)肿瘤大小主要分布在1~4 cm范围。不同肿瘤大小的分组中,1~4 cm组,2型糖尿病合并肾细胞癌患者的GSP和FBG比单纯肾细胞癌组明显增高,差异有统计学意义(P<0.01);5~7 cm和>7 cm的两组,2型糖尿病合并肾细胞癌患者的GSP、血肌酐和FBG明显较单纯肾癌的患者明显增高,差异有统计学意义(P<0.01)。(3)肿瘤不同分期中,肾细胞癌Ⅰ期的患者比例最高(170/280),Ⅳ期所占比例最低(30/280)。在Ⅰ、Ⅱ、Ⅲ、Ⅳ期,2型糖尿病合并肾细胞癌患者的GSP、血肌酐、FBG较单纯肾细胞癌患者明显增高,差异有统计学意义(P<0.01)。结论糖尿病是肾细胞癌发生的高危因素,并与其肿瘤大小及分期相关。
Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) and renal cell carcinoma (RCC) and to find out if diabetes mellitus is a risk factor for renal cell carcinoma. Methods A total of 280 patients with renal cell carcinoma were enrolled and divided into RCC group (n = 122) and RCC + T2DM group (n = 280) according to whether they had type 2 diabetes. A total of 158 patients . The differences of age, gender, size and stage of renal cell carcinoma, glycosylated serum protein (GSP), serum creatinine (Cr) and fasting blood glucose (FBG) were recorded and analyzed. Results (1) Of the 280 patients with renal cell carcinoma, 158 were diabetic. The number of women with renal cell carcinoma who had a history of type 2 diabetes (94 patients) was greater than in men (64 patients). (2) The tumor size mainly distributed in the range of 1 ~ 4 cm. In the groups of different tumor sizes, GSP and FBG in patients with type 1 diabetes mellitus and type 2 diabetes mellitus were significantly higher than those with simple renal cell carcinoma (P <0.01), while those with 5-7 cm and The GSP, serum creatinine and FBG in patients with type 2 diabetes mellitus with renal cell carcinoma more than 7 cm were significantly higher than those with simple renal cell carcinoma, the difference was statistically significant (P <0.01). (3) The proportion of patients with stage I renal cell carcinoma was the highest (170/280) and the lowest was stage IV (30/280) in different stages of cancer. The GSP, serum creatinine and FBG were significantly higher in type I, II, III and IV patients with type 2 diabetes mellitus combined with renal cell carcinoma than those with simple renal cell carcinoma (P <0.01). Conclusion Diabetes mellitus is a risk factor for the development of renal cell carcinoma, which is related to its tumor size and stage.