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探讨阿立哌唑对难治性精神分裂症患者的疗效及安全性。方法：随机选择我院2013年6月～2014年2月住院的难治性精神分裂症患者40人，其中合并有2型糖尿病或糖耐量异常者8人，高血压病者4人，采用阿立哌唑治疗，治疗剂量10～30毫克，根据既往用药情况，减少或停服原抗精神病药，根据病情可合并小剂量SSRIs、心境稳定剂、苯海索片、苯二氮卓类药物等，观察8周。采用阳性与阴性症状量表评定患者的精神症状，不良反应量表评定药物不良反应。结果：治疗第4周阳性症状分、阴性症状分、一般精神病理总分均有显著性下降( P<0.05或P<0.01)，不升高血糖及体重，不良反应轻微。结论：阿立哌唑改善难治性精神分裂症患者的精神症状，有助于缓解一些患者的共患症状如抑郁、焦虑、强迫症状、社交回避等，不明显升高血糖、体重，不良反应少，使用时仍需定期复查实验室指标。“,”Objective:To investigate the efficacy and safety of aripirazole in the treatment for patients with refractory schizophrenia.Methods:Forty patients with refractory schizophrenia who had been hospitalized in our hoapital during June 2013 to February 2014 were involved in the study. Among them,there were eight patients with type 2 diabetes or abnormal glucose tolerance and four ones with hypertension.They were treated with aripirazole,which therapeutic dose was 10-30mg.The antipsychotic drugs which they had been taking before curing with aripirazole must be reduced or stoped.According to every patient’s condition,we should combine with smal doses of SSRIs,mood stabilizers,benzodiazepines,Antane tablets,etc. Then we observed for eight weeks .Results: At the 4th weekend, the scores of positive symptoms ,negative symptoms and general mental pathological symptoms are significantly decreased than before.The adverse reactions are slight.Conclusions: Aripirazole can improve mental symptoms of patients with refractory schizophrenia.It helps to ease some symptoms partly as depression,anxiety,obsessive compulsive disorder, social evade behavior when it combines with some SSRIs,mood stabilizers,benzodiazepines,etc. The laboratory indexes must be reviewed regularly in the course of treatment.