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目的观察肺心病急性期患者空腹血清胰岛素、空腹血糖、胰岛素敏感指数水平变化,探讨肺心病患者是否存在胰岛素抵抗。方法选择2006年11月至2008年12月在我院住院的31例肺心病急性期患者作为实验组,选择同期健康体检31例作为对照组。2组临床基线资料匹配。所有选定的参选者均测定空腹血糖(FBG)、FINS及胰岛素敏感指数(ISI)。FBG采用葡萄糖氧化法测定,FINS采用酶联免疫吸附法测定,ISI采用李光伟等提出的计算方法进行计算。结果实验组FINS水平明显高于对照组〔(16.63±8.74〕vs(6.08±2.53)μIU/ml,P<0.01〕,FBG水平显著高于对照组〔(6.48±2.33)vs(4.79±0.75)mmol/L,P<0.01〕,ISI显著低于对照组〔(-4.26±0.92)vs(-3.26±0.51),P<0.01〕。结论肺心病急性期患者存在胰岛素抵抗,胰岛素抵抗为其重要的危险因素,这为肺心病患者使用胰岛素增敏剂治疗提供了科学依据。
Objective To observe the changes of fasting serum insulin, fasting blood glucose and insulin sensitivity index in patients with acute pulmonary heart disease (CHD) to explore whether there is insulin resistance in patients with pulmonary heart disease. Methods 31 patients with acute cor pulmonale who were hospitalized in our hospital from November 2006 to December 2008 were selected as the experimental group and 31 healthy subjects were selected as the control group. 2 sets of clinical baseline data match. All selected participants tested for fasting blood glucose (FBG), FINS, and insulin sensitivity index (ISI). FBG was determined by glucose oxidation, FINS was determined by enzyme-linked immunosorbent assay, and ISI was calculated by the calculation method proposed by Li Guangwei et al. Results The level of FINS in the experimental group was significantly higher than that in the control group (16.63 ± 8.74 vs 6.08 ± 2.53 μIU / ml, P <0.01), and the levels of FBG in the experimental group were significantly higher than those in the control group (6.48 ± 2.33 vs 4.79 ± 0.75, mmol / L, P <0.01〕, ISI was significantly lower than that in the control group (-4.26 ± 0.92 vs -3.26 ± 0.51, P <0.01) .Conclusion Insulin resistance and insulin resistance are important in patients with acute pulmonary heart disease Of the risk factors, which for pulmonary heart disease patients with insulin sensitizer treatment provides a scientific basis.