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目的探讨低出生体质量儿的危险因素。方法搜集2009年9月至2010年3月出生在苏州大学附属第一医院产科的所有新生儿及其母亲产前的流行病学和临床资料,采用线性回归和Logistic回归模型分析低出生体质量的危险因素。结果单因素分析显示,早产(<37周)、血小板计数<100×109/L、红细胞计数>3.5×1012/L和妊娠期高血压与低出生体质量有关联(P<0.01),其β值(95%CI)分别为-1 032.9(-1 109.8～-955.9)、-99.1(-244.1～-46.0)、-51.3(-134.3～-31.8)和-342.9(-436.6～-249.2);多重线性回归模型显示,早产(<37周)、生育史(≥1次)和妊娠期高血压与出生体质量有关联(P<0.01),其β值(95%CI)分别为-1 000.2(-1 078.1～-922.3)、-212.6(-381.9～-43.3)和-173.4(-245.7～-101.0);多因素Logistic回归模型显示,早产(<37周)和妊娠高血压与低出生体质量有关联(P<0.01),其OR值(95%CI)分别为79.5(46.3～136.4)和3.5(1.9～6.4)。结论早产和妊娠高血压疾病是该院低出生体质量重要的独立危险因素。
Objective To explore the risk factors of low birth weight children. Methods The prenatal epidemiological and clinical data of all newborns and their mothers who were born in the obstetrics department of the First Affiliated Hospital of Soochow University from September 2009 to March 2010 were collected. The linear regression and Logistic regression model were used to analyze the prevalence of low birth weight Risk factors. Results Univariate analysis showed that preterm labor (<37 weeks), platelet count <100 × 109 / L, erythrocyte count> 3.5 × 1012 / L and gestational hypertension were associated with low birth weight (P <0.01) (95% CI) were -1 032.9 (-1 109.8 ~ -955.9), -99.1 (-244.1 ~ -46.0), -51.3 (-134.3 ~ -31.8) and -342.9 (-436.6 ~ -249.2) Multiple linear regression models showed that the β values (95% CI) were -1 000.2 for preterm labor (<37 weeks), fertility history (≥1 times) and gestational hypertension and birth weight (-1 078.1 ~ -922.3), -212.6 (-381.9 ~ -43.3) and -173.4 (-245.7 ~ -101.0) respectively. Multivariate logistic regression showed that preterm labor (<37 weeks) (P <0.01). The OR values (95% CI) were 79.5 (46.3 ~ 136.4) and 3.5 (1.9 ~ 6.4), respectively. Conclusion Preterm and pregnancy-induced hypertension are independent risk factors for low birth weight.