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致病菌幽门螺杆菌(HP)定居于人体胃粘膜,引起各种慢性细菌性胃炎和溃疡,同时也是胃癌发生的一个主要危险因素。早期实验发现,即使体外培养对HP敏感的药物在体内却往往不能根治。现已知HP各菌株的性状如耐药性、粘附特异性和细胞毒素的产生等有着很大的差异。如用各种分子生物学方法进行分型,这种差异就显得更大。一般两个独立的临床标本可用DNA指纹法进行鉴别。在某些抗生素治疗不能根除HP的病人,第2次活检标本似乎与初次标本密切
Pathogenic bacteria Helicobacter pylori (HP) colonize human gastric mucosa, causing a variety of chronic bacterial gastritis and ulcers, but also a major risk factor for gastric cancer. Early experiments found that even in vitro culture of HP-sensitive drugs in the body often can not cure. It is known that there are great differences in the traits of HP strains such as drug resistance, adhesion specificity and cytotoxicity. Such as the use of a variety of molecular biology methods, the difference is even greater. Generally two independent clinical specimens can be identified by DNA fingerprinting. In some antibiotics for patients who can not eradicate HP, the second biopsy appears to be close to the initial specimen