Bridging peripheral nerve defect with chitosan-collagen film

• 作 者: 魏欣 劳杰 顾玉东
• 机 构: Center of Emergency Trauma, Shanghai East Hospital, Shanghai 200120, China“,”Department of Hand Surg
• 出 处: 中华创伤杂志(英文版)
• 发表日期: 2003年3期
• 关键词: Peripheral nerves Nerve regeneration Nerve conduit Collagen Chitosan

Objective: To seek new method for the treatment of peripheral nerve injury. Methods: In rat model with sciatic nerve defect, chitosan-collagen film was sutured into conduit to bridge 5 mm, 10 mm nerve defects. Rats that underwent end-to-end anastomosis were taken as controls. General observation, electrophysiological study, histological study and image analysis were performed at 4, 8, 12 weeks postoperatively. Results: In 5 mm nerve defects, the quality of nerve regeneration was similar to that of the control group. For 10 mm nerve defect, nerve regeneration was inferior to that of the control group. Chitosan-collagen film obviously degraded at 12 weeks postoperatively. Conclusions: Chitosan-collagen film conduit can be used to bridge peripheral nerve defect.