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目的 分析七氟烷和丙泊酚对食管癌单肺通气患者术中和术后肺氧合功能的影响及机制.方法 选取90例胸外科食管癌单肺通气患者, ASA分级为Ⅰ～Ⅱ级, 随机分为对照组与研究组各45例.对照组给予丙泊酚静脉注射, 研究组给予七氟烷维持麻醉.比较2组术中与术后心率、平均动脉压、吸气峰压及脉搏氧饱和度等指标, 采集2组血标本, 测定其氧合指数.采用免疫组织化学法检测2组NF-kB表达水平, 并记录2组并发症的发生情况.结果 2组患者术中与术后心率、平均动脉压、吸气峰压及脉搏氧饱和度比较, 均无明显差异 (P均>0.05);研究组术中与术后动脉血氧分压及氧合指数均明显高于对照组 (P均0.05);研究组肺组织中NF-kB水平低于对照组, 且术后呼吸困难的发生率明显低于对照组 (P0.05); the levels of intraoperative and postoperative pulse oxygen saturation and oxygenation index in the study group were significantly higher than those in the control group (P all0.05). The NF-kB level of lung tissue was lower than that of the control group and the incidence rate of postoperative respiratory difficulties was significantly lower than that of the control group (P0.05). CONCLUSION Compared with propofol, sevoflurane can significantly improve the oxygenation function of patients with esophageal cancer of one lung ventilation, and the mechanism may be raleted to the inhibition of NF-kB expression.