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山莨菪碱具有抑制腺体分泌、散瞳和松弛平滑肌等作用.主要用于解除内脏平滑肌痉挛、抗休克等.近年来的研究发现,有多方面的用途使临床应用也有所扩大.裴迎东、张新德分别报道山莨菪碱在血液病和神经科中的应用.现简介在其他方面的应用,仅供参考.1 治疗重度新生儿窒息杨建平用山莨菪碱抢救重度新生儿窒息44例,并与对照组40例作疗效对比.方法:对新生儿窒息在娩出后立即清除呼吸道分泌物,加压吸氧等综合治疗措施同时,并用山莨菪碱0.5～1Mg/(kg·次)静注,隔15分钟1次,一般4～6次逐渐停药.结果:治疗组治愈39例,死亡5例,治愈率88.6%,对照组治愈24例,死亡16例,治愈率60%.两组相比有显著性差异(P<0.01).作者认为,山莨菪碱解除心、脑、肺、肾和周围血管平滑肌痉挛状态,改善微循环,增加组织供血供氧使窒息得到缓解.并指出,对新生儿窒息应用愈早,效果愈好.
Anisodamine inhibits glandular secretion, mydriasis and relaxation of smooth muscle and other functions.It is mainly used to relieve visceral smooth muscle spasm, anti-shock, etc. In recent years, the study found that there are many uses to make clinical application has also been expanded.Pe Yingdong, Zhang Xinde Respectively reported in the application of anisodamine in hematology and neurology. Brief introduction on other aspects of the application, for reference purposes only .1 treatment of severe neonatal asphyxia Yang Jianping with anisodamine rescue of severe neonatal asphyxia in 44 cases, and the control group 40 cases for curative effect comparison.Methods: Neonatal asphyxia clear respiratory secretions immediately after delivery, pressurized oxygen and other comprehensive treatment measures at the same time, and with anisodamine 0.5 ~ 1Mg / (kg · times) intravenous injection, every 15 minutes 1, usually 4 to 6 times gradual withdrawal.Results: The treatment group cured 39 cases, 5 deaths, the cure rate was 88.6%, 24 cases were cured in the control group, 16 patients died, the cure rate was 60% (P <0.01) .The authors believe that anisodamine relieve heart, brain, lung, kidney and peripheral vascular smooth muscle spasm, improve microcirculation, increase blood supply to the organization to alleviate asphyxia. And pointed out that the neonatal asphyxia The sooner the application, the better the result.