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兹测定氯甲基三甲基硅烷及γ-氯丙基三甲基硅烷与碘化钾、硫氰酸钾及甲醇钠在亲核取代反应中的反应速度常数,并以1-氯丁烷为参比化合物。γ-氯丙基三甲基硅烷与甲醇钠作用时仅发生取代反应,并无氯化氢消除及硅碳键断裂等副反应;而1-氯丁烷与甲醇钠作用时则除取代反应外尚生成约7%丁烯。取代反应的速度常数的比率见表4。从实验结果可以清楚看出,γ-氯丙基三甲基硅烷与亲核试剂的反应速度大致与1-氯丁烷一样,说明在亲核取代反应中硅原子对γ-氯原子的反应性能无影响。而氯甲基三甲基硅烷与亲核试剂作用时则随所用试剂的不同,硅原子对α-氯原子的反应性能有不同的影响。
The determination of chloromethyl trimethyl silane and γ-chloropropyl trimethyl silane and potassium iodide, potassium thiocyanate and sodium methoxide in the nucleophilic substitution reaction rate constant, and 1-chlorobutane as a reference Compound. γ-chloropropyl trimethyl silane and sodium methanolate reaction occurs only when there is no hydrogen chloride elimination and silicon carbon bond cleavage and other side effects; and 1-chlorobutane and sodium methoxide in addition to the reaction was generated in addition to the reaction About 7% butene. The ratio of the rate constant of the substitution reaction is shown in Table 4. From the experimental results, it is clear that the reaction speed of γ-chloropropyltrimethylsilane with the nucleophile is roughly the same as that of 1-chlorobutane, indicating that the reaction of the silicon atom to the γ-chlorine atom in the nucleophilic substitution reaction no effect. However, when chloromethyltrimethylsilane and nucleophile are used, the reactivity of silicon atom to α-chlorine atom varies with the reagents used.