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目的:对参卿止痒洗液进行皮肤急性毒性和皮肤刺激性实验,以了解其安全性。方法:参卿止痒洗液经皮给药用于大鼠背部完整皮肤、破损皮肤,观察其产生急性毒性情况;将临床用浓度的参卿止痒洗液局部涂抹兔破损皮肤及完整皮肤,1次/d,连续7次,逐日观察、并记录各时间点动物局部皮肤的症状表现以评价参卿止痒洗液对皮肤的刺激性。结果:参卿止痒洗液未产生急性毒性;参卿止痒洗液对兔完整皮肤和破损皮肤均无明显刺激性。结论:参卿止痒洗液以临床浓度、5倍临床浓度、10倍临床浓度外用给药安全,无急性皮肤毒性反应、皮肤与全身刺激反应。
OBJECTIVE: To test the skin acute toxicity and skin irritation of Shen-Qing Zhiyang Lotion to understand its safety. Method: Shenqing antipruritic lotion was applied to the intact skin on the back of rats to damage the skin and to observe its acute toxicity. The clinically treated Shenqin Anti-itch Lotion was topically applied to the damaged skin and intact skin, 1 time / d, 7 times in a row, daily observation, and record the symptoms of local skin of animals at various time points to evaluate the anti-acne lotion skin irritation. Results: Shen Qing antipruritic lotion did not produce acute toxicity; Shen Qing antipruritic lotion on rabbit intact skin and damaged skin were no obvious irritant. Conclusion: Shenqing antipruritic lotion with clinical concentration, 5 times the clinical concentration, 10 times the clinical concentration of topical drug delivery, no acute dermal toxicity, skin and systemic irritation.