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Ets家族是一个数量有限 ,但十分重要的基因家族 ,其包含有与血管形成有关的激活因子 ,因此某些Ets蛋白可促进肿瘤血管新生 ,进而促进肿瘤恶化。又由于许多控制转移和浸润的基因具有Ets的反应性 ,故某些Ets蛋白可有促进肿瘤的浸润和转移的作用。如果大多数类型的肿瘤细胞是由于Ets蛋白的表达而获得浸润和转移的能力 ,那么通过使用核糖体酶抑制剂、反义寡核苷酸或者显性非正常功能的Ets突变体 ,将可能有助于改进目前广泛使用的恶性肿瘤治疗方案
The Ets family is a limited but important family of genes that contain angiogenesis-related activators so that certain Ets proteins promote tumor angiogenesis, thereby contributing to tumor progression. Since many of the genes that control metastasis and invasion have Ets reactivity, some of the Ets proteins can promote tumor invasion and metastasis. If most types of tumor cells are capable of infiltrating and metastasizing due to the expression of Ets protein then by using ribosomal enzyme inhibitors, antisense oligonucleotides, or Ets mutants that are dominantly dysfunctional, it would be possible to have Help to improve the currently widely used treatment of malignant tumors