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目的 观察急性脑血管病时下丘脑 垂体 肾上腺皮质轴的功能变化。方法 应用放射免疫方法检测急性脑血管病患者肾上腺皮质激素 (Cor) ,促肾上腺皮质激素 (ACTH)的含量。结果 急性脑血管病患者血清ACTH、Cor含量均高于对照组 ,差异有显著性 (P <0 .0 1) ,血清ACTH、Cor含量与脑损伤范围成正比 ,急性脑血管病恢复期血清ACTH、Cor含量明显低于急性期 ,有显著差异 (P <0 .0 1)。结论 急性脑血管病患者血清ACTH、Cor含量均有改变 ,是可逆的。
Objective To observe the functional changes of the hypothalamus pituitary adrenal cortex axis in patients with acute cerebrovascular disease. Methods Radioimmunoassay was used to detect the levels of adrenocorticotropic hormone (COR) and adrenocorticotropic hormone (ACTH) in patients with acute cerebrovascular disease. Results Serum levels of ACTH and Cor in patients with acute cerebrovascular disease were significantly higher than those in the control group (P <0.01). Serum levels of ACTH and Cor were positively correlated with the extent of brain injury. ACTH , Cor content was significantly lower than the acute phase, there was a significant difference (P <0.01). Conclusion Serum levels of ACTH and Cor in patients with acute cerebrovascular disease are both changed and are reversible.