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1977年 Rizzetto 等应用 HBV 健康携带者的血清,根据荧光抗体法对肝组织中的 HBc 抗原进行探讨,虽然发现被染色的肝细胞核呈 HBc 抗原样,但用电镜观察核内,完全看不到 Core 颗粒,提示是与 HBc 抗原、HBs 抗原、HBe 抗原不相同的抗原抗体系统,以此作为δ抗原、抗体而报道。此后,明确了此抗原与有关 HBV 抗原不同,即所谓如无 HBV 或其它肝炎病毒的帮助不能增殖的不完全(defecfive)感染因子.近几年,由于 RIA 试剂盒的普及,虽然欧美各国
In 1977, Rizzetto et al used serum of HBV healthy carriers and discussed the HBc antigen in liver tissue according to the fluorescent antibody method. Although it was found that the stained hepatocyte nucleus showed the HBc antigen, the electron microscope was used to observe the nucleus and no Core Particles, suggesting that HBc antigen, HBs antigen, HBe antigen is not the same antigen antibody system, as δ antigen, antibody and reported. Since then, it has been clarified that this antigen is different from the related HBV antigens, namely, the so-called imperfect (defecfive) infectious factors that can not be proliferated without the help of HBV or other hepatitis viruses.In recent years, due to the popularity of RIA kits,