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目的 :探讨Fas、FasL蛋白在喉鳞癌 (LSCC)组织中的表达及意义。方法 :采用SABC免疫组化法检测 4 2例LSCC及 2 0例手术切缘正常组织中Fas及FasL ,并与LSCC病理分级、临床分期及颈淋巴结转移相比较。结果 :Fas及FasL在LSCC中阳性率分别为 4 7.6 %和 6 4 .3% ,与在正常喉组织阳性率 90 .0 %和 2 0 .0 %相比 ,差异有显著性意义 (P <0 .0 5 )。Fas阳性率与肿瘤分级分期无显著相关性 (P >0 .0 5 ) ,与肿瘤转移有关 (P <0 .0 5 ) ;FasL阳性率与肿瘤分级、分期及转移密切相关 (P <0 .0 5 )。Fas与FasL的表达无显著相关性。结论 :Fas及FasL表达异常可能参与喉鳞癌的发生和发展 ;检测Fas与FasL可望作为判定喉鳞癌预后的潜在指标。
Objective: To investigate the expression and significance of Fas and FasL protein in laryngeal squamous cell carcinoma (LSCC). Methods: SABC immunohistochemical method was used to detect Fas and FasL in 42 cases of LSCC and 20 cases of normal surgical margin, and compared with LSCC pathological grade, clinical stage and cervical lymph node metastasis. Results: The positive rates of Fas and FasL in LSCC were 47.6% and 64.3%, respectively, which were significantly different from those in normal laryngeal tissues (90.0% and 2.0%, P < 0 .0 5). There was no significant correlation between the positive rate of Fas and tumor staging (P> 0.05), which was correlated with tumor metastasis (P <0.05). The positive rate of FasL was closely related to tumor grade, stage and metastasis (P <0.05). 0 5). Fas and FasL expression no significant correlation. Conclusion: The abnormal expression of Fas and FasL may be involved in the occurrence and development of laryngeal squamous cell carcinoma. The detection of Fas and FasL may be used as potential indicators to determine the prognosis of laryngeal squamous cell carcinoma.