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The bovine chromaffin cells (HCC) implanted into the subarachnoid space can release analgesic substances such as opioid peptides and catecholamines. Clinical trials have provided the evidence that the implantation of polyvinylchloride (PVC) hollow fiber encapsulated HCC by surgery can relief the pain in cancer patients. In the present study, BCC were encapsulated in alginate-polylysine-alginate (APA) microericapsules which protect the grafting of xenogeneic cells from host immune system and allow BCC to function effectively without using immunosuppression agents. The microencapsulated BCCs (5 ×106-8 × 106) were transplanted into the subarachnoid space L,_5 of 17 patients who suffered from chronic cancer pain and had to have long-term administration of analgesics. The pain scores and morphine intake test showed that microencapsulated BCC graft totally stopped the chronic pain in three of the patients over a period of 200 days and in the other three over a period of 100 days. The results suggest that AP
The bovine chromaffin cells (HCC) implanted into the subarachnoid space can release analgesic substances such as opioid peptides and catecholamines. Clinical trials have provided the evidence that the implantation of polyvinylchloride (PVC) hollow fiber encapsulated HCC by surgery can relief the pain in cancer patients In the present study, BCC was encapsulated in alginate-polylysine-alginate (APA) microericapsules which protect the grafting of xenogeneic cells from host immune system and allow BCC to function effectively without using immunosuppression agents. The microencapsulated BCCs (5 × 106-8 × 106) were transplanted into the subarachnoid space L,_5 of 17 patients who suffered from chronic cancer pain and had to have long-term administration of analgesics. The pain scores and morphine intake test showed that microencapsulated BCC graft completely stopped the chronic pain in Three of the patients over a period of 200 days and in the other three over a period of 100 days. The resul Ts suggest that AP