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目的 探讨宫颈癌组织端粒酶活性在诊断预测患者预后方面的意义。方法 应用多聚酶链反应 -酶联免疫吸附法 (PCR- EL ISA)对病理确诊的 35例宫颈癌组织和 12例宫颈炎组织进行端粒酶活性半定量检测。结果 35例宫颈癌组织中 31例端粒酶阳性表达 ,端粒酶阳性率为 88.6 % (31/ 35 )。 12例宫颈炎组织中有 2例端粒酶阳性表达。端粒酶 A值的高低与组织分化、临床期别有关 ,分化差、晚期癌 A值明显增高。结论 宫颈癌组织中有端粒酶活性表达 ;端粒酶活性的检测有助于宫颈癌的诊断、鉴别诊断和预测预后 ;端粒酶活性将成为宫颈癌的肿瘤标记物。
Objective To investigate the significance of telomerase activity in the prognosis of patients with cervical cancer. Methods Semi-quantitative detection of telomerase activity was performed in 35 cases of cervical cancer and 12 cases of cervicitis diagnosed by PCR-ELISA. Results The telomerase positive expression was found in 31 cases of 35 cases of cervical cancer, the positive rate of telomerase was 88.6% (31/35). Twelve patients with cervicitis had telomerase positive expression in 2 cases. The level of telomerase A was closely related to the differentiation and clinical stage, the differentiation was poor, and the value of A in advanced stage was significantly higher. Conclusion Telomerase activity is expressed in cervical cancer tissues. The detection of telomerase activity contributes to the diagnosis, differential diagnosis and prognosis of cervical cancer. Telomerase activity will become the tumor marker of cervical cancer.