Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor γ a

• 作 者: CHEN Wei-chang LIN Mao-song BA
• 机 构: Department of Gastroenterology, First Affiliated Hospital, Suzhou Univercity, Suzhou 215006, China“,
• 出 处: 中华医学杂志（英文版）
• 发表日期: 2005年17期
• 关键词: PPARγ colorectal cancer apoptosis rosiglitazone 15d-PGJ2

As a ligand-dependent transcriptional factor, peroxisome proliferator-activated receptor (PPAR) γ was expressed in several human cancer cells and PPARγ activation could induce cells growth inhibition.1-4 In this study we investigated the PPARγ expression in colon cancer cell line HT-29 and checked the inducement of apoptosis by two PPARγ specific agonists rosiglitazone and 15d-PGJ2. In addition, we also observed the protein expressions of PTEN and p-Akt1 before and after treatment with rosiglitazone and examination whether activation of PPARγ could increase the expression of PTEN in colon cancer cells.