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目的探讨白细胞介素及肿瘤坏死因子与女性不孕的关系。方法对２６例抗精子抗体阳性（ＡｓＡｂ＋）、１５例抗精子抗体阴性（ＡｓＡｂ－）的不孕妇女及１３例已生育的健康妇女血清中的白细胞介素Ⅵ、Ⅷ及肿瘤坏死因子进行了检测。结果抗精子抗体阳性的不孕妇女血清中白细胞介素Ⅵ含量显著性地高于抗精子阴性组和健康对照组，白细胞介素Ⅷ及肿瘤坏死因子三组间无显著性差异。结论抗精子抗体阳性的不孕妇女血清中ＩＬ－６含量增高可能与不孕症的发生发展存有一定联系
Objective To investigate the relationship between interleukin, tumor necrosis factor and female infertility. Methods The levels of interleukin Ⅵ, Ⅷ and tumor necrosis factor-α (TNF-α) in sera of 26 infertile women with antisperm antibody (AsAb +), 15 infertile women with antisperm antibody (AsAb-) and 13 healthy women . Results The level of IL-6 in serum of infertile women with anti-sperm antibody was significantly higher than that of anti-sperm-negative group and healthy control group. There was no significant difference between the three groups of IL-8 and TNF-α. Conclusions The increase of IL-6 in the sera of infertile women with anti-sperm antibody may be related to the occurrence and development of infertility