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通过对150 名学生接种伤寒Vi 多糖菌苗后3 年追踪观察表明:接种伤寒Vi 多糖菌苗后体内可快速产生Vi 抗体,免后1 月抗体阳性率为97-3% ,GMT 为38-34,且Vi 抗体在体内至少可维持2 年以上的较高水平;免后3 年加强1 针,Vi抗体又恢复到较高水平,阳性率为83-3 % ,GMT 为25-20,但没有达到初免后1 月水平。结合伤寒Vi 多糖菌苗流行病学观察资料,说明伤寒Vi 多糖菌苗接种后对人体至少有2 年的保护作用,免后加强的最佳时间不是3 年,免后间隔多长时间加强,其免疫效果最佳需进一步研究。
The results of 3-year follow-up after vaccination of 150 students with the bacteriophage Vi polysaccharide vaccine showed that the in vivo production of Vi antibody could rapidly produce Vi antibody after vaccinated with typhoid Vi polysaccharide vaccine. The antibody positive rate was 97-3% in January and the GMT was 38-34 , And Vi antibody in the body to maintain at least 2 years above a high level; 3 years after the needles to strengthen a needle, Vi antibody and returned to a higher level, the positive rate of 83-3%, GMT of 25-20, but no Reached the level of January after the initial exemption. Combined with the epidemiological observation of typhoid Vi polysaccharide vaccine, the results showed that the protective effect of typhoid Vi polysaccharide vaccine for at least 2 years after vaccination, the best time to strengthen after not 3 years, The best immune effect needs further study.