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1971～1977年共196例儿童急性淋巴细胞性白血病(ALL),研究其治疗前的免疫球蛋白(Ig)水平与临床表现,疗效及预后的关系。采用免疫扩散平板法测定患儿 Ig 水平,结果155例(79%)在正常范围,31例(16%)增高,10例(5%)至少有1种 Ig 降低。低 Ig 组中低 IgG 4例,低 IgA 4例,IgG 和 IgA 同时降低1例,IgA 降低而 IgM 增高1例。有4例作了膜表面标记检查,B 细胞型白血病1例,非 B 非 T 型3例,另有3例开始时白细胞计数超过20×10~9/L,可能是 T 细胞型 ALL,但均无前纵隔肿块。
A total of 196 children with acute lymphoblastic leukemia (ALL) were investigated from 1971 to 1977 to study the relationship between their immunoglobulin (Ig) levels before treatment and clinical manifestations, curative effects and prognosis. Ig levels were measured in children with immunodiffusion plate method. Results 155 (79%) were in the normal range, 31 (16%) were elevated and 10 (5%) had at least 1 Ig reduced. In low Ig group, there were 4 cases with low and medium IgG, 4 cases with low IgA, 1 case with IgG and IgA reduced, IgA decreased and IgM increased in 1 case. There were 4 cases of membrane surface marker examination, 1 case of B cell leukemia, 3 cases of non-B non-T type, and 3 cases of the beginning of leukocyte count more than 20 × 10 ~ 9 / L, may be T cell ALL, but No anterior mediastinum mass.