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目的：研究用ＨＬＡ不合多个脐血移植治疗难治性儿童白血病。方法：选择难治性白血病患儿，给予强烈化学治疗杀灭残存白血病细胞，再用多个脐血混合移植解救处于严重抑制状态的骨髓，以缓解白血病，延长生命。结果：治疗６例，年龄２５～１６岁，均为男性。用ＶＡＣ或ＡＶ方案化疗后，约１１ｄ外周血颗粒细胞降至零。输注脐血后平均１３ｄ外周血白细胞升至１０×１０９／Ｌ，６０ｄ内骨髓象正常，全部患者达到完全缓解。随诊１～４年，３例死亡，３例分别存活３６、４４、２０个月。结论：混合脐血移植对难治性白血病有较好疗效，其治疗作用机理值得进一步探讨。
Objective: To study the treatment of refractory childhood leukemia with HLA incompatible cord blood transplantation. Methods: Children with refractory leukemia were selected to give strong chemotherapy to kill residual leukemia cells, and multiple cord blood transplantation was used to rescue the bone marrow in the severely inhibited state to relieve leukemia and prolong life. Results: The treatment of 6 cases, aged 2 5 to 16 years old, are men. After chemotherapy with VAC or AV regimen, the granulosa cells in peripheral blood were reduced to zero at about 11 days. Peripheral blood leukocytes rose to 1 0 × 109 / L on average 13 days after cord blood infusion, and bone marrow was normal within 60 days. All patients achieved complete remission. After 1 to 4 years of follow-up, 3 died and 3 survived 36, 44 and 20 months respectively. Conclusions: Mixed cord blood transplantation has a good effect on refractory leukemia, and its therapeutic mechanism is worth further exploration.