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目的探讨脓毒血症患者胆碱酯酶水平与患者病情及预后的关系。方法 2007年6月-2009年6月,将89例脓毒血症患者设定为脓毒血症组,进行血清胆碱酯酶测定及APACHEⅡ评分;另择82例健康人为正常组,测定血清胆碱酯酶值,比较两者之间差异;89例脓毒症患者按病况再分为存活组及死亡组,比较两者之间血清胆碱酯酶及APACHEⅡ评分差异。结果治疗前脓毒血症组胆碱酯酶水平明显低于正常组,有统计学意义(P<0.01);脓毒血症组APACHEⅡ评分与血清胆碱酯酶呈负相关;死亡组APACHEⅡ评分明显高于存活组,而血清胆碱酶低于存活组(P<0.01)。结论胆碱酯酶同APACHEⅡ评分呈负相关,能明显反映脓毒症患者病情严重程度及预后。
Objective To investigate the relationship between the level of cholinesterase and the severity and prognosis of patients with sepsis. Methods From June 2007 to June 2009, 89 patients with sepsis were selected as sepsis group, and serum cholinesterase and APACHEⅡ scores were determined. Another 82 healthy subjects were selected as normal group, Choline esterase value, the difference between the two; 89 cases of sepsis patients according to the condition is divided into survival group and death group, the difference between the two serum cholinesterase and APACHE Ⅱ score. Results Before treatment, the level of cholinesterase in sepsis group was significantly lower than that in the normal group (P <0.01); the APACHEⅡ score in sepsis group was negatively correlated with serum cholinesterase; the APACHEⅡ score in death group Significantly higher than the survival group, while serum cholinease was lower than the survival group (P <0.01). Conclusion Cholinesterase was negatively correlated with APACHE Ⅱ score, which can obviously reflect the severity and prognosis of patients with sepsis.