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发现院内深部真菌感染73例(91例次),占同期院内感染8.7％。应用病例-对照研究,单因素分析发现:9项因素与真菌感染有关,包括患者年龄、基础疾病、住院天数和次数、原有其它院内感染、抗菌药物使用种类及天数、留置导尿、恶性肿瘤等。住院天数和次数、抗生素使用天数和种类、基础疾病的严重程度等多水平因素与真菌感染有明显量-效关系。logstic回归多因素分析结果表明:多种抗菌药物的使用、原有其它院内感染(医源性因素)、60岁以上老人及1岁以内的婴幼儿、致死性疾病(宿主因素)是最主要危险因素。
Found 73 cases of deep fungal infection in the hospital (91 cases), accounting for 8.7% of the same period of nosocomial infection. According to the case-control study and univariate analysis, nine factors were found to be associated with fungal infection, including age, underlying disease, days and frequency of hospitalization, other original nosocomial infections, types and days of antibacterial use, indwelling catheterization, malignancy Wait. The number of days of hospitalization, the number and type of antibiotics used, the severity of underlying diseases and other multi-level factors have a significant dose-effect relationship with fungal infections. Logistic regression multivariate analysis showed that the most important risk factors for fatal diseases (host factors) were the use of various antibiotics, other original nosocomial infections (iatrogenic factors), the elderly over 60 and infants under 1 year old factor.