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目的探讨高三尖杉酯碱(HHT)联合三氧化二砷(As2O3)、羟基脲治疗高白细胞慢性粒细胞白血病(CML)的疗效和毒副作用。方法对2004年11月-2009年12月行高三尖杉酯碱联合As2O3、羟基脲治疗高白细胞CML患者21例的疗效和不良反应进行分析。结果经高三尖杉酯碱联合As2O3、羟基脲治疗后3～6个疗程,21例CML患者中完全缓解15例,占71%;部分缓解2例,占10%;总有效率81%;未缓解4例,占19%。不良反应仅表现乏力、纳差、恶心、脱发。结论 HHT联合As2O3、羟基脲是治疗高白细胞CML一种有效率高,临床容易开展,安全性好的方法。
Objective To investigate the efficacy and side effects of homoharringtonine (HHT) combined with arsenic trioxide (As2O3) and hydroxyurea in the treatment of high white blood cell chronic myeloid leukemia (CML). Methods The efficacy and adverse reactions of 21 cases of high leukocyte CML treated with homoharringtonine combined with As2O3 and hydroxyurea in November 2004-December 2009 were analyzed. Results After 3 to 6 courses of treatment with Homoharringtonine combined with As2O3 and hydroxyurea, 15 cases (71%) were completely relieved in 21 cases of CML, 2 cases were partly relieved (10%), and the total effective rate was 81%. 4 cases were relieved, accounting for 19%. Adverse reactions showed only weakness, anorexia, nausea, hair loss. Conclusions HHT combined with As2O3 and hydroxyurea is an effective and safe method for the treatment of high white blood cell CML.