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A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.
It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.