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自然杀伤细胞(NK)在口腔疾病中的作用尚不清楚。现仅知外周血NK细胞的细胞毒性与炎性牙周病之间存在正相关性。在慢性粘膜病的早期及复发性阿弗它口腔溃疡中,NK细胞介导的抗体依赖性细胞毒性作用增强。因此,作者研究了一组常见牙周病病原菌能否活化NK细胞。在这项研究中,作者用标准~(51)Cr-释放试验测定外周血淋巴细胞(PBL)经E.Corrodens等6种牙周病病原菌活化后杀伤红白血病细胞株K562和M14、
The role of natural killer (NK) cells in oral diseases remains unclear. It is only known that there is a positive correlation between the cytotoxicity of peripheral blood NK cells and inflammatory periodontal disease. NK cell-mediated antibody-dependent cytotoxicity is enhanced in early and recurrent aphthous oral ulcers of chronic mucosal disease. Therefore, the authors investigated whether a group of common periodontal pathogens can activate NK cells. In this study, the authors used standard ~ (51) Cr-release assay to determine that peripheral blood lymphocytes (PBLs) were activated to kill erythroleukemia cell lines K562 and M14 by six pathogenic bacteria of periodontal disease, such as E. Cordens.