论文部分内容阅读
G~-杆菌的类脂A部分是内毒素的核心毒性成份,与几乎所有临床重要的G~-杆菌的类脂A部分呈现交叉免疫反应。为研究抗G~-内毒素抗原决定簇的特异性抗体,类脂A也适合作为一种试验性抗原。为评价含有IgG、IgM和IgA的多克隆免疫球蛋白制剂对脓毒性休克的辅助治疗效果,进行了前瞻性随机临床试验。选择符合脓毒性休克标准的病人55例随机分为两组,治疗组以免疫球蛋白制剂治疗(第1天
The lipid A portion of G ~ -bacteria is the core toxic component of endotoxin, which cross-reacts immunologically with the lipid A portion of almost all clinically important G ~ -bacteria. Lipid A is also suitable as a test antigen for the study of specific antibodies to G ~ - endotoxin epitopes. A prospective randomized clinical trial was conducted to evaluate the adjuvant therapeutic effect of polyclonal immunoglobulin preparations containing IgG, IgM and IgA on septic shock. Fifty-five patients who were eligible for septic shock were randomly assigned to two groups. The treatment group received immunoglobulin preparation (Day 1