论文部分内容阅读
四圜素类应用于临床已有十多年历史,它的严重副作用却在近几年来才引起注意,该刊编者简单地综述了该类药物在临床应用及动物实验方面的毒性反应,以引起临床医师的警惕。1957年就有人注意到服用该类药物后有荧光物质沉积在骨和肿瘤组织内,但不知其对正常骨质生长与发育有无影响,1962年才发现应用治疗量的四圜素类即可使药物沉积在骨和乳牙组织内而影响其发育,因此建议在妊娠期的最后三个月内不要轻易地服用四圜素类。
Tetracycline has been used clinically for more than 10 years and its serious side effects have only attracted attention in recent years. The editors briefly reviewed the toxicological responses of these drugs in clinical application and animal experiments to cause Clinician’s vigilance. In 1957 it was noticed that the use of such drugs after the fluorescent material deposited in the bone and tumor tissue, but I do not know their normal bone growth and development have no effect, only in 1962 found that the amount of therapeutic application of tetrachlorethylene can be Drugs deposited in bone and deciduous tissue affect its development, therefore, it is recommended that during the last trimester of pregnancy do not take tetraspanins easily.